Federal and state, in parallel.
US financial services sit under a parallel federal-and-state supervisory structure. At the federal level, the Financial Crimes Enforcement Network (FinCEN) supervises anti-money-laundering compliance under the Bank Secrecy Act; the Office of the Comptroller of the Currency (OCC) supervises nationally-chartered banks; the Consumer Financial Protection Bureau (CFPB) supervises consumer financial products under federal consumer-protection statutes; and the Federal Trade Commission (FTC) supervises unfair-or-deceptive practices.
At the state level, each state has its own banking or financial-services regulator (the New York Department of Financial Services is the most consequential for fintech; California, Massachusetts, Illinois, and Texas all matter too) and its own money-transmitter and lender-licensing regimes. Working in the US under the partner-bank pattern means engaging with both the federal regulators that supervise the partner and the state regulators that govern the customer-facing activity.